XIIIth INTERNATIONAL SYMPOSIUM on SPERMATOLOGY
Registration is now closed on-line; for queries regarding on-site registration, please send a message to casm-sal[at]medh.ki.se.
Overview of registration of participation, accomodation, submission of free communications and related information - click HERE
Requests for further information, please send an e-mail to casm-sal[at]medh.ki.se.
List of Free Communications at the end of this page!!
What do the creatures below have in common?
Their sperm are expected at the Spermatology Symposium in Stockholm, May 9-13 2018!!
In 2018 the International Symposium on Spermatology will take place just outside Stockholm, Sweden. In a conference resort situated on the rural island of Lidingö, scientists dedicated to mutual gain in knowledge of spermatozoa will meet to present interesting data and to discuss.
The general aim of the Symposium is thus to bring together scientists from a wide spectrum of research fields – human, domestic animals and other mammals, vertebrates, insects and even plants. All with an interest in the function of the spermatozoon – a common feature for sexual reproduction but still extremely varied. By exploring the variability, a better understanding of male reproductive functions can develop. Focus will be on mechanisms of physiology and pathophysiology rather than diagnosis and treatment.
The XIII International Symposium will focus on comparative biology and rich opportunities for spontaneous discussions and exchange of ideas and views.
The format will be keynote lectures by invited speakers, followed by presentations on specific aspects of the general theme of the session. There will be room for free communications, oral or by poster. Experimental studies will be given priority over clinical studies of patient populations.
The Symposium is composed on seven themes related to spermatozoa.
Titles may be amended. TBA= speaker to be announced
Welcome and Inaugural Presentations - Wednesday evening, May 9
- Welcome address - Lars Björndahl, Sweden
- 50 years of Spermatology Symposia - Hideo Mohri, Japan
- Swedish Spermatologists - Ulrik Kvist, Sweden
- Welcome Reception
Are Spermatozoa at the Verge of Extinction?
Following reports on declining sperm numbers in human, there is an interest in understanding if this a universal problem, affecting also other species. What is the role of environmental influence? The fate of endangered species is also a matter that might be linked to a general decline in sperm production.
- Temporal Trends in human sperm counts - Hagai Levine, Israel
- The Controversy Surrounding the Temporal Decline in Human Sperm Counts - TBA
- Epidemiological aspects of sperm count studies - Anders Ekbom, Sweden
- Environmental toxicants and sperm production in men and animals - Christiaan de Jager, South Africa
- Panel Discussion - Ulrik Kvist, Sweden (moderator)
Sperm DNA – Protection and Delivery of a Complete and Undamaged Genome
The purpose of the spermatozoon is to deliver half of the genome of a new individual to the oocyte. The DNA must be protected from harmful influences and still be able to deliver the undamaged DNA at the right time.
- Post-testicular sperm oxidation : what to be afraid of? - Joel Drevet, France
- Sperm as a possible source of transgenerational epimutations and genetic instability - Liliana Ramos, The Netherlands
Sperm Competition, Evolution and Sperm-Egg Interaction
One aspect of spermatozoa important to sperm development in many species is sperm competition. Once at the site of fertilization the spermatozoon must find the key to the fertilization lock.
- The sexual cascade: evolutionary dynamics of sperm competition - Geoffrey Alan Parker, United Kingdom
- Genotype-phenotype associations in relation to evolution of sperm form and function - Eduardo Roldan, Spain
- From mouse to human: New aspects of sperm transport and fertilization using cutting edge technologies - Sabine Koelle, Ireland
- First Snapshot of How Sperm Binds the Egg at the Molecular Level - Luca Jovine, Sweden
Genetic Aspects of Sperm Production and Performance and its Effects on the Offspring
Advances in genetic methodology opens new possibilities to understand normal and abnormal sperm structure and function. Björn Afzelius discovered dynein arms in 1958 and described the immotile-cilia-syndrome 20 years later. Also other ciliary defects can cause infertility and structural defects should be traced to the genetic origins. Other aspects involve how selection of haploid germ cells can influence the offspring, and how.
- When cilia go bad - the complex genetics of ciliopathies - Anna Lindstrand, Sweden
- Haploid selection within a single ejaculate increases offspring fitness - Simone Immler, United Kingdom
- Effect of cryopreservation on the genome of sperm in animal and humans - Julia Kopeika, United Kingdom
CASA - Advances and Challenges: The S is for…
There have been two major consensus papers about CASA – the first from the Spermatology meeting in Cairns in 1994, the second from an ESHRE SIGA campus meeting in San Miniato in 1998 – but many of the recommendations from those meetings are still overlooked or ignored.
The aim of this session is to revisit these recommendations and decide which are still relevant today, in other words, what is still left to do to bring CASA to the point where it is the “go to” solution for all relevant work. The concept of this session is to consider what CASA is currently being used for in the lab, and what it could be used for if it had the capacity.
- Introduction - Sharon Mortimer, Canada
"The S is for ... semen"
- CASA in the clinical andrology laboratory - David Mortimer, Canada
- Process and data management of CASA in animal spermatozoa - Gerhard van der Horst, South Africa
"The S is for ... sperm"
- Relationship between flagellar movement and head trajectory at higher frame rates – is this still a valid approach for CASA? - Sumio Ishijima, Japan
- Research applications: reproductive toxicology, epidemiological studies, drug evaluation - Natalie Aneck-Hahn, South Africa
- If we were developing CASA today, what would be the most important features? Who would have the responsibility for what: is “product out” or “market in” the better approach? - Sharon Mortimer, Canada (moderator)
Challenges for Sperm Function In Vitro
Studies of spermatozoa as well as clinical routines for treatment and cryopreservation often means that spermatozoa are taken out of their natural environments. This session aims at outlining in vitro challenges for spermatozoa in vitro and what can be done to overcome them.
- Common challenges for sperm in vitro - causes and consequences - Ulrik Kvist, Sweden
- Main effects of in vitro manipulation of spermatozoa - Elisabetta Baldi, Italy
Heterogeneity of Sperm Morphology and Laboratory Techniques to Overcome Assessment Challenges
There appears to be a difference in sperm morphology between species with competition on sperm level and those with competition on individual level. In species, like human, with pleiomorphic spermatozoa there is a special challenge describing and characterizing morphology aspects that are relevant to the function of the male reproductive organs and to male reproductive success. Categorization schemes must be based on relevant investigations of individuals of different reproductive success and be used consistently due to standardized training and techniques. Formal standardization could be a meaningful way of turning WHO recommendations into a proper universal standard.
- Comparative aspects of sperm morphology as analyzed by CASA - Gerhard van der Horst, South Africa
- Progress with sperm morphology after the STRICT CRITERIA era - Roelof Menkveld, South Africa
- A structured approach for the assessment of human sperm morphology - Susan A Rothmann, USA
- Improvement of WHO recommendations and development of a formal ISO standard - Lars Björndahl, Sweden
The following titles have been accepted for Oral Presentations
- Complex population of chromatin-associated proteins identified in mature sperm of the European sea bass (Dicentrarchus labrax) through high-throughput proteomic analysis
- Does Cinnamtannin B-1 protects or destabilize sperm DNA? Contradictory results of SCSA® and TUNEL
- Peripubertal serum dioxin concentrations and sperm methylome of young Russian adults
- Sperm DNA fragmentation in human split ejaculates
- A Novel Atypical Centriole in Human Spermatozoa Functions in the Zygote
- Adaptive modifications of the regulation of sperm motility in the diversification of reproductive modes of amphibians
- Mutations in the CFAP-coding Genes Lead to Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella
- Sperm selection within a single ejaculate affects reproductive ageing in the offspring
- The mouse-specific Gly-to-Cys mutation in mammalian acrosin is a cause of impairment in proteolytic activity
- Chemical and genetic approaches to identify C. elegans spermiogenesis-related factors
- Effect of melatonin on capacitation and Ca2+ distribution in red deer spermatozoa
- Unraveling the signal transduction pathways of novel mitochondrial peroxiporins in activated piscine spermatozoa
- Prolonged chilled preservation and preliminary investigations of energy production of koala (Phascolarctos cinereus) spermatozoa
- Sperm motion and metabolism in physiological conditions
- Gametes collision in fresh water fish: evidences of guidance and selection
- Lectin-binding pattern changes on the bovine sperm after differently induced process of capacitation
- A simple but dramatic technical improvement in the Diff Quik stain protocol used for preparing specimens for sperm morphology evaluation
The following titles have been accepted for Poster Presentations
- The moves do matter: Sperm chemotactic behavior captured using a microfluidic chip
- Use the Nanoparticles to improve the quality of Human semen for capacitation and Acrosome reaction
- Sperm as components of microrobots: why or why not?
- Action of zona pellucida glycoproteins in mouse and human sperm
- Intracellular Viruses Identification in Sperm Assay of Patients with Fertility problems
- Genetically Determined Forms of Asthenozoosprmia and Sperm Ultrastructure in Asthenozoospermic Patients
- Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice
- PMCA and NCKX are expressed, but not involved in activation of sturgeons sperm motility
- Effects of Enterococcus faecalis and Stenotrophomonas maltophilia on boar sperm viability
- In-vitro sperm characteristics of electroejaculated chilled semen using different extenders in Droughtmaster bulls
- Chemotactic and chemokinetic features of rainbow trout ovarian fluid
- Sperm selection in the female reproductive tract
- Male gametogenesis of malaria parasites, Plasmodium berghe
- DTT identifies samples with impaired sperm chromatin stability which have increased risk for DNA strand breaks
- Modulation from helical waves generated by sliding movement of outer doublet microtubules into planar waves
- Association between vitamin D intake and vitamin D status with semen parameters among young men in Southern Spain
- Flow patterns around a human sperm in different viscous media
- Utilisation of a novel drug screening strategy for drug discovery of compounds that improve human sperm motility
- Single cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success
- Sperm from a patient with a homozygous in-frame deletion in CATSPERE lack functional CatSper expression and fail to fertilise at IVF
- Changes in pattern of protein phosphorylation in bull testicular and epididymal sperm
- Crucial egg tetraspanins detected also on bovine sperm
- Improved sperm motility after short abstinence: The role of accessory sex gland secretions
- fCASA – Bringing high-throughput flagellar analysis to CASA
- cAMP modulates Ca2+-mediated regulation of sperm flagellar waveform
- Epicatechin can preserve oxidative balance of bovine spermatozoa subjected to ferrous ascorbate-induced oxidative stress
- Protective Effects of Epicatechin on Bovine Spermatozoa under Induced Oxidative Stress
- HSP90A may control spermatogenesis of Asian elephant (Elephas maximus) cryptorchid testes
- Bending initiation and molecular-motor synchronization in the sperm flagellum
- Sodium alginate solution reduces fish sperm sedimentation and enhances their survival during short-term storage
- Comparison of computer assisted sperm analysis of motility patterns using two different CASA instruments
- Definition of bull sperm hyperactivity by Computer Assisted Sperm Analyzer
- Spermiogenesis as a phylogenetic marker in birds and reptiles
- Ejaculate evolution in external fertilizers: Influenced by sperm competition or sperm limitation?
- Sperm form and function: what do we know about the role of sexual selection?
- Sperm surface proteins as potential binding receptors for zona pellucida
- Static oxidation-reduction potencial in fresh, extended and refrigerated dog semen
- Improved sperm function in human sperm subpopulations: a model for studying subfertility
- Calaxin is essential for ciliary formation in nodal monocilia but not in sperm flagella or epithelial multicilia
- Absence of BSP protein have not important effect on male infertility
- Assessment of the cytotoxicity of chitosan via CASA
- Electron microscopic sperm tail abnormalities among men with severely reduced sperm motility
- Comparison manual motility assessment and CASA
- Effects of increasing semen osmolality on sperm functional capacity